The largest organ in the body is the skin, which weighs one-third of what we do. We must take care of it since it protects us from the outside world and helps to regulate our body temperature. There, we also grow in touch sensitivity and even light vision. Skin disorders like acne or eczema may be challenging for people to manage while trying to lead regular lives. Thankfully, Hydroxypinacolone Retinoate (HPR) can help your skin heal and prevent reoccurring problems. Your skin will benefit from HPR in the following ways.
What is Hydroxypinacolone Retinoate?
The ever-expanding retinoid family, a collection of powerful vitamin A derivatives, includes hydroxypinacolone retinoate (HPR), an ester of retinoic acid, and a somewhat more recent, more stable component.
HPR is a multifunctional substance that interacts with skin by attaching to its retinoic acid receptors in the top layers of the skin. Although it has been demonstrated to be gentler than retinoic acid (tretinoin) when applied topically, it still communicates directly with these receptors, thus those with more reactive or sensitive skin may want to consider HPR as a possible substitute for pure retinol.
Besides being quite moderate, research has shown that this retinoic acid ester has anti-aging and blemish-reduction effects on the skin. When paired with retinol glycospheres and papain glycospheres, studies reveal that HPR helped to reduce the frequency of minor breakouts as well as the redness connected with them with little disruption to the skin barrier.
HPR is a multipurpose skincare component that has been shown in studies to minimize the appearance of fine lines and wrinkles and to improve uneven tone, so those who want to address both these issues may consider using it.
HPR can have a favourable effect on skin at levels as low as.02%. But, when incorrectly packaged, such as when kept in jars exposed to light and air, its efficiency is significantly reduced. HPR must be stored in air-tight, opaque packaging, much like all other antioxidants and derivatives of vitamin A, to maintain its potency.
What is the science behind hydroxypinacolone retinoate?
HPR, also known as hydroxypinacolone retinoate, is a retinoic acid ester (tretinoin; medically prescribed retinoid). There is a claim that HPR is just as effective as retinoids that are prescribed, but without unpleasant side effects like flaking, skin irritation, or redness. HPR is governed similarly to a prescription retinoid in various nations.
Retinoids bind to RAR and RXR receptors, which in turn causes biological effects such as boosting blood vessel formation, enhancing cell proliferation and turnover, and reducing pigmentation and oil production. This explains why vitamin A has anti-aging and anti-acne properties.
The effects get stronger the closer a molecule is to retinoic acid. The issue is that HPR, unlike retinol, retinyl, and aldehydes, does not require enzymatic conversion to deliver retinoid-like actions.
What are the benefits of Hydroxypinacolone Retinoate?
1. Increased elastin in the skin
A study revealed that the skin’s elastin was boosted by the HPR. Our skin can stretch and reposition itself thanks to elastin fibres. Elastin loss causes our skin to sag and droop. Our skin is kept elastic and smooth by elastin, which helps it to appear firm and youthful, in conjunction with collagen.
The most effective strategy to preserve your elastin is to apply sunscreen every day, just like you can do with collagen.
2. Increased collagen production
One of the most prevalent proteins in the human body is collagen. It can be discovered in our hair, nails, and connective tissue (tendons, etc.). The dermis, the thickest skin layer, is made up of it to a degree of roughly 70 per cent. Around age 25, collagen production begins to decline. Up until we reach menopause, when it drops much more quickly, it slows by roughly 1% annually. Smoking and sun damage hasten this process.
Collagen acts as the “scaffolding” that keeps our skin strong and smooth. Our skin starts to lose its structure, sag, and wrinkle as a result of collagen loss, which accelerates the ageing process. Large pores can also result from low levels of collagen and elasticity in the skin, which causes the skin to sag and stretch the pore, giving the impression that it is larger. Whatever your skin type, this is possible, however, it might be more obvious if you have a lot of natural oils.
3. Improve skin tone
Many people who use retinoids discover that their skin gets this fantastic “glow” after a few months. To the touch, it appears firmer, softer, and smoother. These are all elements that go towards having a beautiful skin tone.
When we are teenagers and young adults, our skin has these qualities. Retinoids like HPR truly give our skin the appearance and feel of youth by accelerating the rate at which our skin cells renew. Our skin generates fresh cells on a 28- to 40-day cycle, which travels from the base of our skin to the epidermis and then eventually flakes off. This process takes only approximately 28 days when we are young, and our skin looks healthy. Our skin becomes rougher, dryer, and duller as we age because the old skin cells linger on our outermost skin layers for a longer period of time (40 days).
Improved skin tone is the result of retinoids like HPR speeding up skin cell turnover. All of the individuals in the tiny study I mentioned above said their skin texture had improved, which includes features like radiance, softness, firmness, and general skin condition. You may have heard that exfoliating helps to make your skin look more radiant by removing the top layer of dead skin cells. Although the technique is different from how retinoids function, both offer excellent outcomes.
4. Fades Age Spots
Dark patches on our skin sometimes referred to as hyperpigmentation, can develop at any age but become more prevalent as we age. After turning 40, I have defiantly noticed more. They primarily occur by sun exposure, and I find that summer is the worst time for them.
In this trial, HPR and a vitamin C derivative reduced black spots on participants’ skin by up to 50 per cent. It’s important to remember that this study was conducted by the HPR manufacturer and is relatively tiny. So it’s unquestionably inferior to the collagen and elastin research I mentioned earlier.
However, given that most retinoids do perform effectively on hyperpigmentation, it seems logical to assume that HPR will do the same based on what I observe in those other research. There is no justification for anticipating HPR to be different.
5. Reduce Fine Lines and Wrinkles
Using retinoids for women presumably begins for the most frequent reason—to make wrinkles less noticeable. Fine lines around the eyes are typically the first to appear, followed by larger wrinkles on the forehead, in the space between the eyebrows, and around the lips.
The most effective wrinkle treatment, outside of injectables like Botox, is retinoids like HPR. They work well to both lessen existing wrinkles and stop the development of new ones. However, it does take time; you should let it at least 12 weeks before noticing any reduction in fine lines. Prior to noticing a difference in deeper wrinkles, it may take up to six months.
Side effects of Hydroxypinacolone Retinoate
The true effects of hydroxypinacolone retinoate are still being studied, thus it is best to consult a doctor or dermatologist before using it all over the body because the manufacturer’s promises about how it would assist the skin lack any scientific support.
What are the other alternatives of Hydroxypinacolone Retinoate?
Retinol, retinyl palmitate, retinaldehyde, and prescription retinoids are other alternatives. Retinoic acid is the most effective kind, however, using creams that require a prescription almost always has negative effects. Retinaldehyde, retinol, and retinyl derivatives are the next most potent topicals that just need a single conversion step.
Your end goals and, more significantly, your skin’s tolerance to irritants will influence the retinoids you choose to include in your skincare routine.
Final thoughts on Hydroxypinacolone Retinoate
The truly amazing thing about HPR is that it works at the cellular level to promote the formation of new cells, rather than just protecting your skin on the surface as a cream or serum may. This is something that very few over-the-counter skincare actives can achieve for your skin.
HPR successfully reverses the indications of ageing by increasing the production of collagen and elastin, something that the majority of other cosmetic chemicals can only claim to achieve. This anti-aging component will therefore continue to be a part of my skincare regimen.